Have you ever seen someone who chugs down bottles of alcohol without showing the tiniest signs that they’re getting drunk? People who have this ‘magical’ ability to not get drunk after consuming a considerable amount of alcohol are often often dubbed as the ‘whales’ of the group, referencing the common saying that they ‘drink like a fish’.
But why does this actually happen? Why are some people better at handling relatively large doses of alcohol?
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When a drinker has too much too drink on a regular basis, gradually, his/her body develops a kind of tolerance to alcohol. In this context, tolerance means that after regular drinking, the consumption of a given amount of liquor produces fewer effects than it does for a casual or occasional drinker. In other words, you could say that an alcohol-tolerant person must consume more liquor to produce the same effect, or the same ‘high’, if you will.
Some people are better at handling alcohol
Some people are simply born with a low sensitivity to alcohol. In simple words, they possess the ability to go round after round of beers, but show minimal effects.
So, if you sit a person with low alcohol sensitivity (or an alcohol tolerant person) with someone who drinks only occasionally, then despite consuming the same amount of liquor (say, 4 glasses of wine each), the former would mostly be alright, while the latter would be stuttering, blabbering and spilling their deepest secrets.
It’s usually seen that people born into families with a history of alcoholism are more likely to be born with low alcohol sensitivity. Researchers have not been able to identify exactly why this happens, but it often does.
Some people develop alcohol tolerance
There is also the other class of people who actually develop a tolerance towards alcohol by constantly drinking large amounts of it. It all comes down to the fact that the more you drink alcohol, the more your brain and body adjust to the rising doses of alcohol in your system. The upshot is that you need to drink even more to achieve the same ‘high’.
How does the body develop alcohol tolerance?
The most important aspect of alcohol tolerance occurs in the brain.
The two main neurotransmitters in the brain that are relevant to this discussion are GABA (performs inhibitory functions) and glutamate (performs excitatory functions, i.e., the opposite of GABA).
Alcohol significantly increases the activity of the GABA system – it does some of that directly, while some of that is done by inhibiting glutamate activity. Now, the brain’s job is to maintain homeostasis (a self-regulating process by which biological systems tend to maintain stability while adjusting to external conditions), so that you don’t die.
In a bid to do that, the brain upregulates (i.e., increases the activity of) the glutamate system to compensate for the increased activity of the GABA system. That’s one of the reasons why people who drink a lot can easily handle large doses of liquor… doses that could potentially kill others. This is because the brains of long-term alcoholics have made compensatory changes within the glutamate system.
Of course, this is a massive over-simplification of the entire process; in reality, there are many other factors involved that influence how someone develops an alcohol tolerance.
The liver also plays a role. As you may know already, the liver is responsible for the processing of alcohol in our bodies. Liver cells have an organelle known as the Smooth Endoplasmic Reticulum (SER), whose job it is to break down nasty substances, such as alcohol and drugs.
When you drink a lot on a regular basis, the liver registers that it needs to process more than its usual quota of alcohol. Thus, in response, it drastically increases the surface area of cells’ SER (over a period of just a few days). This aids in processing a larger volume of alcohol.
If you ever find yourself in a medical laboratory and have a chance to see the liver cells of an alcoholic under a microscope, you will notice that the SER in their cells are much larger than in the liver cells of a non-alcoholic. That’s another reason why people become tolerant towards alcohol and will boldly match anyone drink for drink, any night of the week!