Can Normal Cells Divide Like Cancer Cells?

Yes, if mutated enough or subjected to enough amounts of radioactive material, normal cells can eventually become cancerous cells and divide abnormally.

Imagine that while chopping vegetables, you accidentally cut yourself. Ideally, to “heal” the wound, your skin cells would divide and make more cells. But what makes these cells stop or start the process of cell division? Is it possible for these cells to keep dividing endlessly?

How does cell division work?

Cell division is the process where a parent cell divides itself to form two or more cells. The parent cell is the one that divides, and the resulting cells are called the daughter cells. Cell division primarily occurs in two different ways:

Mitosis

Division of a cell, mitosis concept, 3D illustration - Illustration(Kateryna Kon)s

An illustration of the process of mitosis: the parent cell divides into two daughter cells, which are replicas of the parent cell. (Photo Credit : Kateryna Kon/ Shutterstock)

Mitosis is a type of cell division in which the cell duplicates all of its contents, including the genetic material, i.e., the DNA. This division results in the formation of two daughter cells, which are replicas of the parent cell. Ideally, the cells generate signals to stop or initiate cell division based on when and where the cells are needed.

Meiosis

Meiosis is a fairly complicated process in comparison to the simple division of mitosis. In meiosis, the genetic number, (which is usually 46) is reduced to half for the sperm and egg cells. The genetic number is reduced to 23 so that when the sperm and egg cells fuse again to form an embryo, the combination will restore the genetic number back to 46. The genetic number is also referred to as the “chromosome number”. Chromosomes carry the genetic material inside them and the chromosome number is representative of the number of chromosomes found in one cell of that particular organism.

Meiosis Partition Scheme - Vector( Emre Terim)s

A meiotic division, mostly consisting of the division of genetic material. The end result of the division are cells with a chromosome number 23. When the blue and orange end products combine again, it forms a single cell with a chromosome number 46, which then results in the embryo. (Photo Credit : Emre Terim/ Shutterstock)

Meiosis is the sexual cell division that takes place when the division of genetic material takes place. This type of division results in the formation of four daughter cells. These daughter cells, unlike in mitosis, are not replicas of the parent cell. It is due to this fact that meiosis allows for genetic variation, also known as “DNA shuffling”.

Cancer

Cancer is a group of related diseases involving abnormal cell growth that can invade other tissues and parts of the body. The cell growth, in this case, would occur through mitosis. The uncontrolled and continuous state of cells performing mitosis and therefore affecting other cells is known as the cancerous state. The cells that are dividing abnormally are known as the cancerous cells.

Vector isolated illustration of malignant and benign tumor in healthy tissue. Spreading of cancer cells, tumor development(Pikovit)s

Benign (left) and malignant (right) tumors. (Photo Credit : Pikovit/ Shutterstock)

Due to the large amount of divisions, the cells that are growing and dividing abnormally start to grow in a cluster or a lump. This cluster of cancerous cells is known as a tumor. There are two types of tumors—benign and malignant. Benign tumors are tumors that do not spread, while malignant tumors are tumors that spread to other tissues.

What is the difference?

If we go back to the question posed at the beginning of this article, it is now possible to add a few more elements to the question to make it more refined. Is it possible for regular skin cells to divide uncontrollably and form tumors? How does the division of a regular cell differ from the division of a cancerous cell?

The answer lies in understanding why the cancerous, abnormal growth happens in the first place.

Division mistake

Sometimes during mitosis, a mistake occurs in the replication of the genetic material. Anything ranging from one piece of genetic material getting copied twice to the genetic material getting damaged can result in what is known as a mutation. There needs to be at least a dozen mutations for a normal cell to turn into a cancerous cell, and it usually takes years of slow growth and development for a tumor to form in this way. If a division mistake happens once or twice, the body has contingency plans and is able to rectify those mistakes.

Double helix DNA molecule with modified genes , Correcting mutation by genetic engineering , 3d illustration - Illustration(nobeastsofierce)s

A DNA unit (genetic material of the cell) in the process of forming new DNA. (Photo Credit : nobeastsofierce/ Shutterstock)

Exterior mutations

Cells can also undergo mutations brought about by exterior agents, such as smoking or getting exposed to radioactive materials. These are induced mutations, which do not take place due to the cell’s fault. In this case, the genes become damaged over time, so the formation of tumors and their spread is faster in comparison to a mutation caused by the cell.

Woman smoking a cigarette. Smoke spread. - Image(Stanislaw Mikulski)s

Cigarettes contain tobacco, which can create mutations in cells. Tobacco is an external generator of cellular mutations. (Photo Credit : Stanislaw Mikulski/ Shutterstock)

Inherited mutations

At times, before the formation of an embryo, the genetic material of the daughter cells can inherit any faults or mistakes present in the parent genetic material. This means that if the parent cell had undergone mutation and then performs meiosis, the existing mutations will be copied in the genetic material of the daughter cells.

In Conclusion

As seen above, cell division can provide answers about why cancerous and abnormal growth takes place.  Therefore, we see that yes, if enough mutations take place during the division to heal a cut, it can result in cancerous cells. Fortunately, the chances of that many mutations occurring in day-to-day activities and cell division are very, very low. At the same time, what we need to remember is that cell division is almost a continuous process in our body. With the human body composed of roughly 37 trillion cells, it’s not impossible for mutations in cells to arise naturally. Many people get cancer without the consumption of tobacco or without any exposure to radioactive substances. The human body does make mistakes, at times, mainly because of the large number of complicated processes it handles; this is simply a reality that we need to accept!

Realistic pink ribbon, breast cancer awareness symbol, isolated on white. Vector illustration, eps10. - Vector(mything)S

A breast cancer awareness ribbon. (Photo Credit : mything/ Shutterstock)

This is why awareness and knowledge about a disease such as cancer is vital in today’s world.  There has been a rise in awareness concerning cancer in modern times and, rightfully so, we all acknowledge that, for now, this state of the body is incurable.

Even if our body has contingency plans, it can happen anywhere, whether or not it’s directly caused by you. Hence, in such times as ours, trying to stay updated on the topic and increasing awareness about it is all we can do.

References

  1. National Institutes Of Health (NIH)
  2. Cancer Research UK
  3. National Cancer Institute
  4. Arizona State University
The short URL of the present article is: http://sciabc.us/E2bkV
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About the Author:

Raag is pursuing an undergraduate degree in Pune (India). He displays a keen interest in almost everything, understanding how things work and what we surround ourselves with, and takes it upon himself to make the acquiring of knowledge through this interest as simple as possible.

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